Th22, but not Th17 Might be a Good Index to Predict the Tissue Involvement of Systemic Lupus Erythematosus
Identifieur interne : 001149 ( Main/Exploration ); précédent : 001148; suivant : 001150Th22, but not Th17 Might be a Good Index to Predict the Tissue Involvement of Systemic Lupus Erythematosus
Auteurs : Xu-Yan Yang [République populaire de Chine] ; Hui-Ying Wang [République populaire de Chine] ; Xiao-Ying Zhao [République populaire de Chine] ; Li-Juan Wang [République populaire de Chine] ; Qing-Hua Lv [République populaire de Chine] ; Qing-Qing Wang [République populaire de Chine]Source :
- Journal of Clinical Immunology [ 0271-9142 ] ; 2013-05-01.
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Abstract
Abstract: Purpose: T-helper (Th) cells abnormalities are considered to be associated with the pathogenesis of Systemic lupus erythematosus (SLE). Recently, The Th22 cells have been identified and implicated in the pathogenesis of autoimmune diseases such as Rheumatoid arthritis (RA), although therir role in Systemic lupus erythematosus (SLE) remains unclear. The present study intends to investigate their roles in SLE. Methods: Clinical data were collected in 65 SLE patients and 30 healthy controls. The patients were divided into active and inactive groups. CD4+IFN-γ−IL-17−IL-22+Tcells (Th22 cells),CD4+ IFN-γ−IL-22−IL-17+T cells (Th17 cells),and CD4+ IFN-γ+ (Th1 cells) were assayed by flow cytometry. Serum interleukin-22 (IL-22) and IL-17 levels were measured by enzyme-linked immunosorbent assay. Results: The main observation focused on increased Th22 cells in patients with sole lupus skin disease and decreased Th22 cells in patients with sole lupus nephritis. Likewise, concentrations of serum IL-22 were increased in patients with sole lupus skin disease, and decreased in patients with sole lupus nephritis. Additionally, there was a positive correlation between the percentage of Th22 cells and IL-22 production. The percentage of Th17 cells or concentration of serum IL-17 correlated positively with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Conclusion: Th22 seems to be a more significant index to predict the tissue involvement of SLE than Th17, although Th17 may play a role in the activity of SLE.
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DOI: 10.1007/s10875-013-9878-1
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but not Th17 Might be a Good Index to Predict the Tissue Involvement of Systemic Lupus Erythematosus</title><author><name sortKey="Yang, Xu Yan" sort="Yang, Xu Yan" uniqKey="Yang X" first="Xu-Yan" last="Yang">Xu-Yan Yang</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 310009, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Wang, Hui Ying" sort="Wang, Hui Ying" uniqKey="Wang H" first="Hui-Ying" last="Wang">Hui-Ying Wang</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Allergy and Clinical Immunology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 310009, Hangzhou, Zhejiang</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhao, Xiao Ying" sort="Zhao, Xiao Ying" uniqKey="Zhao X" first="Xiao-Ying" last="Zhao">Xiao-Ying Zhao</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Rd, 310009, Hangzhou, Zhejiang</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country></affiliation></author><author><name sortKey="Wang, Li Juan" sort="Wang, Li Juan" uniqKey="Wang L" first="Li-Juan" last="Wang">Li-Juan Wang</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 310009, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Lv, Qing Hua" sort="Lv, Qing Hua" uniqKey="Lv Q" first="Qing-Hua" last="Lv">Qing-Hua Lv</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology Laboratory, Institute of cancer research, Zhejiang University, 310009, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Wang, Qing Qing" sort="Wang, Qing Qing" uniqKey="Wang Q" first="Qing-Qing" last="Wang">Qing-Qing Wang</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology, Institute of Basic Medical Sciences,College of Medicine, Zhejiang University, 310058, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Clinical Immunology</title><title level="j" type="abbrev">J Clin Immunol</title><idno type="ISSN">0271-9142</idno><idno type="eISSN">1573-2592</idno><imprint><publisher>Springer US; http://www.springer-ny.com</publisher><pubPlace>Boston</pubPlace><date type="published" when="2013-05-01">2013-05-01</date><biblScope unit="volume">33</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="767">767</biblScope><biblScope unit="page" to="774">774</biblScope></imprint><idno type="ISSN">0271-9142</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0271-9142</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Systemic lupus erythematosus</term><term>T helper 1</term><term>T helper 22</term><term>T helper17</term><term>interleukin-17</term><term>interleukin-22</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Purpose: T-helper (Th) cells abnormalities are considered to be associated with the pathogenesis of Systemic lupus erythematosus (SLE). Recently, The Th22 cells have been identified and implicated in the pathogenesis of autoimmune diseases such as Rheumatoid arthritis (RA), although therir role in Systemic lupus erythematosus (SLE) remains unclear. The present study intends to investigate their roles in SLE. Methods: Clinical data were collected in 65 SLE patients and 30 healthy controls. The patients were divided into active and inactive groups. CD4+IFN-γ−IL-17−IL-22+Tcells (Th22 cells),CD4+ IFN-γ−IL-22−IL-17+T cells (Th17 cells),and CD4+ IFN-γ+ (Th1 cells) were assayed by flow cytometry. Serum interleukin-22 (IL-22) and IL-17 levels were measured by enzyme-linked immunosorbent assay. Results: The main observation focused on increased Th22 cells in patients with sole lupus skin disease and decreased Th22 cells in patients with sole lupus nephritis. Likewise, concentrations of serum IL-22 were increased in patients with sole lupus skin disease, and decreased in patients with sole lupus nephritis. Additionally, there was a positive correlation between the percentage of Th22 cells and IL-22 production. The percentage of Th17 cells or concentration of serum IL-17 correlated positively with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Conclusion: Th22 seems to be a more significant index to predict the tissue involvement of SLE than Th17, although Th17 may play a role in the activity of SLE.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement><orgName><li>Université de Zhejiang</li></orgName></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Yang, Xu Yan" sort="Yang, Xu Yan" uniqKey="Yang X" first="Xu-Yan" last="Yang">Xu-Yan Yang</name></region><name sortKey="Lv, Qing Hua" sort="Lv, Qing Hua" uniqKey="Lv Q" first="Qing-Hua" last="Lv">Qing-Hua Lv</name><name sortKey="Wang, Hui Ying" sort="Wang, Hui Ying" uniqKey="Wang H" first="Hui-Ying" last="Wang">Hui-Ying Wang</name><name sortKey="Wang, Li Juan" sort="Wang, Li Juan" uniqKey="Wang L" first="Li-Juan" last="Wang">Li-Juan Wang</name><name sortKey="Wang, Qing Qing" sort="Wang, Qing Qing" uniqKey="Wang Q" first="Qing-Qing" last="Wang">Qing-Qing Wang</name><name sortKey="Zhao, Xiao Ying" sort="Zhao, Xiao Ying" uniqKey="Zhao X" first="Xiao-Ying" last="Zhao">Xiao-Ying Zhao</name><name sortKey="Zhao, Xiao Ying" sort="Zhao, Xiao Ying" uniqKey="Zhao X" first="Xiao-Ying" last="Zhao">Xiao-Ying Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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